Accessing the Cyclopenta[c]pyridine substructure: development of an Enamine/Enal Cycloaddition-Pyridine formation methodology

Author

Benjamin Kester, Kenyon College

Date of Award

5-18-2010

Document Type

Thesis

Degree Name

Bachelor of Arts

First Advisor

Hofferberth, John E.

Abstract

The scope and limitations of a novel methodology to prepare molecules with the cyclopenta[c]pyridine carbon framework was examined. Substrates were prepared with differing substitution at specific positions along the eight-carbon scaffold and their ability to form cyclopenta[c]pyridine derivatives was examined. Substrates were evaluated using two novel reactions to form the cyclopenta[c]pyridine structure: a two-step cycloaddition-pyridine formation, and a one-step tandem method. Early results suggest substrate substitution patterns dramatically influence the operation of the reaction manifold.

Comments

Includes bibliographical references: pages 65-67

Recommended Citation

Kester, Benjamin, "Accessing the Cyclopenta[c]pyridine substructure: development of an Enamine/Enal Cycloaddition-Pyridine formation methodology" (2010). Honors Theses. 28.
https://digital.kenyon.edu/honorstheses/28

Rights Statement

All rights reserved. This copy is provided to the Kenyon Community solely for individual academic use. For any other use, please contact the copyright holder for permission.