Date of Award
Bachelor of Arts
Hofferberth, John E.
The scope and limitations of a novel methodology to prepare molecules with the cyclopenta[c]pyridine carbon framework was examined. Substrates were prepared with differing substitution at specific positions along the eight-carbon scaffold and their ability to form cyclopenta[c]pyridine derivatives was examined. Substrates were evaluated using two novel reactions to form the cyclopenta[c]pyridine structure: a two-step cycloaddition-pyridine formation, and a one-step tandem method. Early results suggest substrate substitution patterns dramatically influence the operation of the reaction manifold.
Kester, Benjamin, "Accessing the Cyclopenta[c]pyridine substructure: development of an Enamine/Enal Cycloaddition-Pyridine formation methodology" (2010). Honors Theses. 28.