Evaluation of OAT1 and OATP1 in A. Aegypti through coinjection of dyes with Probenecid, Naringin

Authors

Logan Coleman, Kenyon CollegeFollow
Matthew F. Rouhier, Kenyon CollegeFollow

Document Type

Poster

Publication Date

Summer 2023

Abstract

The mosquito species Aedes aegypti is responsible for the spread of Zika, Dengue, and Yellow fever viruses, which account for 70,00 deaths annually1. When taking blood meal or drinking water, mosquitoes can ingest their body weight in foreign materials, and need a strong filtration mechanism to survive the resulting urinary and renal stresses. I assessed the efficacy of two of these Organic Anion Transporters, OAT1 and OATP1, using anionic and cationic dyes (measurable ‘xenobiotics’) with varying size with competitive inhibitors Probenecid and Naringin to determine the efficiency of the mosquito filtration system.

Recommended Citation

Coleman, Logan and Rouhier, Matthew F., "Evaluation of OAT1 and OATP1 in A. Aegypti through coinjection of dyes with Probenecid, Naringin" (2023). Kenyon Summer Science Scholars Program. Paper 623.
https://digital.kenyon.edu/summerscienceprogram/623