Exploring the Origins of T Peripheral Helper Cells

Authors

Eva Illuzzi, Kenyon College
Nardos Cheru, Yale University
David Hafler, Yale University
Tomokazu Sumida, Yale University

Document Type

Poster

Publication Date

Summer 2022

Abstract

Interactions between B cells and T helper cells (CD4+) are central to the function of our immune system. Yet, these interactions can turn pathologic and lead to the development of autoimmune diseases. A subset of CD4+ T cells, known as T peripheral helper cells (Tph), has been observed in the circulation and tissue of patients with autoimmune diseases. These cells, unlike the more well understood T follicular helper cells (Tfh), facilitate B cell help at the site of inflammation as opposed to lymphoid organs where Tfh cells are commonly found. The Tph profile shares expression of CXCL13, IL-21, and high levels of PD-1 with Tfh cells but does not express chemokine receptor CXCR5. Therefore, these Tph cells are often defined as PD-1hi CXCR5- CD4+ T cells. Here, we exposed naive and memory CD4+ T cell populations to pro-inflammatory cytokines to induce this Tph cell profile. The combination of cytokines, IFN-β and TGF-β, proved most promising in induction of the Tph population.

Recommended Citation

Illuzzi, Eva; Cheru, Nardos; Hafler, David; and Sumida, Tomokazu, "Exploring the Origins of T Peripheral Helper Cells" (2022). Kenyon Summer Science Scholars Program. Paper 576.
https://digital.kenyon.edu/summerscienceprogram/576