Date of Award
Bachelor of Arts
Formation of the cyclopenta[c]pyridine substructure using a novel one- and two-step method was examined using various linear 1,8-enedial substrates. Methods to prepare 1,8-enedial intermediates with appropriate functionality to form a small family of natural products containing the cyclopenta[c]pyridine substructure were devised, and the performance of such intermediates helped to define the scope and limitation of these novel synthetic protocols. Finally, the utility of this methodology was demonstrated through the total synthesis of tecostidine and the formal synthesis of boschniakine and indicaine.
Adler, Snow, "Development and Optimization of a Novel Synthesis of Natural Products Containing the Cyclopenta[c]pyridine Substructure" (2013). Honors Theses. 104.