Document Type


Publication Date

Summer 2023


The Aedes aegypti mosquito is known as one of the most dangerous mosquitoes due to its ability to spread Dengue, which puts more than 3.9 billion people in danger. Insecticides remain the primary tool to prevent disease spread by A. aegypti, but insecticide resistance is growing therefore new methods are needed. One possible target is the mosquito’s pathway for removing foreign toxins. Our study aims to identify the presence of cation xenobiotic transporters such as the OCTN protein AAEL012443 and OCT AAEL009206. The chosen inhibitors disarrayed the influx/efflux and their built-up toxicity impact was monitored by differentiating the type and concentrations of inhibitors. After multiple trials of injecting mosquitoes with various inhibitors, we found that mosquitoes injected with 10mM OCTN and OCT inhibitors exhibited a higher mortality than the mosquitoes with 1mM. This result gave us confidence that OCT and OCTN proteins exist in mosquitoes and further research is suggested to extend our understanding.



Rights Statement

In Copyright - Non-Commercial Use Permitted