Document Type
Poster
Publication Date
Summer 2024
Abstract
Coordination compounds are essential in various applications, from catalysis in industrial processes to drug delivery systems in medicine to the design of smart sensors in material science. Understanding the chiral properties of these compounds can greatly enhance their performance, as molecular chirality plays a pivotal role in biological recognition and material functionality. Circular dichroism (CD) and Fluorescence-detected Circular Dichroism (FDCD) are two powerful spectroscopy techniques for probing the chiral properties of coordination compounds by understanding how they interact with polarized light. In this study, we explored the CD and FDCD behavior of coordination compounds, focusing on Tris(ethylenediamine) cobalt (III) chloride and Methylene blue (MB) complexed with β-cyclodextrin. The measurements were performed using multiple lasers, revealing distinct absorption and emission patterns indicative of the chiral properties of all tested complexes. The signal intensities varied with different concentrations and the alignment of polarized light, highlighting the system's sensitivity to molecular structure and light modulation. Our future work will aim to expand these methodologies to additional molecular systems with a focus on optimizing detection limits and exploring broader applications in chemical and biological systems.
Recommended Citation
Orco, Tasnim Islam and Keller, James, "Amplification of Circular Dichroism Signal Through Fluorescence Detection" (2024). Kenyon Summer Science Scholars Program. Paper 684.
https://digital.kenyon.edu/summerscienceprogram/684