Document Type


Publication Date

Summer 2022


Eighteen quinone methide precursors (QMPs) were synthesized to test their efficacy at resurrecting organophosphorus-aged acetylcholinesterase. This library of QMPs is based on a phenol framework, and the alkyl groups were chosen based on promising results from similar QMP libraries. The QMPs were synthesized via two methods. The quinone methide precursors with a cyclic R’ group were synthesized via a Suzuki Coupling reaction. The QMPs with conjugated R’ groups were synthesized via a Wittig reaction. Both synthetic pathways ended with a Mannich reaction which installed one of five different aminomethyl groups.



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