Cutinase: A Powerful Biocatalyst for Polyester Synthesis by Polycondensation of Diols and Diacids and ROP of Lactones
Humicola insolens Cutinase (HIC) catalyzed polymerization reactions were investigated to gain insight into the potential of Cutinase from Humicola insolens as a novel catalyst for polymerization reactions. It was found that the immobilized HiC is a powerful catalyst for both polycondensation of diols and diacids and ring opening polymerization reactions of lactones. The optimal activity of immobilized HIC was at 70 °C. The immobilized HiC was inactive for catalysis of L-lactide and (R,S)-β-butyrolactone ROP. HiC-catalyzed ROP of ε-CL in toluene and in bulk and of PDL in toluene was successfully performed giving high molecular weight polymers.
Hunsen, Mo; Azim, Abul; Mang, Harald; Wallner, Sabine R.; Ronkvist, Asa; Xie, Wenchun; and Gross, Richard A. “Cutinase: a powerful biocatalyst for polyester synthesis by polycondensation of diols and diacids and ROP of lactones,” ACS Symposium Series, Ch17, pp 263-274.
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