Development and Optimization of a Novel Synthesis of Natural Products Containing the Cyclopenta[c]pyridine Substructure

Author

Snow Adler, Kenyon College

Date of Award

5-16-2013

Document Type

Thesis

Degree Name

Bachelor of Arts

First Advisor

Hofferberth, John

Abstract

Formation of the cyclopenta[c]pyridine substructure using a novel one- and two-step method was examined using various linear 1,8-enedial substrates. Methods to prepare 1,8-enedial intermediates with appropriate functionality to form a small family of natural products containing the cyclopenta[c]pyridine substructure were devised, and the performance of such intermediates helped to define the scope and limitation of these novel synthetic protocols. Finally, the utility of this methodology was demonstrated through the total synthesis of tecostidine and the formal synthesis of boschniakine and indicaine.

Comments

Includes bibliographical references (p. 66-69)

Recommended Citation

Adler, Snow, "Development and Optimization of a Novel Synthesis of Natural Products Containing the Cyclopenta[c]pyridine Substructure" (2013). Honors Theses. 104.
https://digital.kenyon.edu/honorstheses/104

Rights Statement

All rights reserved. This copy is provided to the Kenyon Community solely for individual academic use. For any other use, please contact the copyright holder for permission.