Title

Enantiodiscrimination of methamphetamine by circular dichroism using a porphyrin tweezer.

Document Type

Article

Publication Date

5-2010

Abstract

Using exciton-coupled circular dichroism (ECCD) spectroscopy, our lab was able to differentiate between the two enantiomers of methamphetamine using a commercially available porphyrin tweezer as an achiral host. The host-guest complex formed with (+)-(S)-methamphetamine produced a negative bisignate-shaped ECCD spectrum, whereas the complex formed with (-)-(R)-methamphetamine produced a positive one. This sensitive technique could serve as an alternative method for the enantiodiscrimination of chiral methamphetamine, a commonly abused drug in the United States.

Journal

Chirality

Volume

22

Issue

4

First Page

398

Last Page

402