Enantiodiscrimination of methamphetamine by circular dichroism using a porphyrin tweezer.
Using exciton-coupled circular dichroism (ECCD) spectroscopy, our lab was able to differentiate between the two enantiomers of methamphetamine using a commercially available porphyrin tweezer as an achiral host. The host-guest complex formed with (+)-(S)-methamphetamine produced a negative bisignate-shaped ECCD spectrum, whereas the complex formed with (-)-(R)-methamphetamine produced a positive one. This sensitive technique could serve as an alternative method for the enantiodiscrimination of chiral methamphetamine, a commonly abused drug in the United States.
Anderson, M. Wilcox, K. Guericke, M. Chu, H. Wilson, M.V. Wilson, E. Lucas, K. Holmes, A.E. Enantiodiscrimination of methamphetamine by circular dichroism using a porphyrin tweezer Chirality 2010, 22(4), 398-402.